Search for dissertations about: "thesis on studies of sumoylation"

Showing result 1 - 5 of 9 swedish dissertations containing the words thesis on studies of sumoylation.

  2. 1. The role of SUMO pathway in pathophsiology of skeletal muscle

    Author : Arvind Venkat Namuduri; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino acids. READ MORE

  4. 2. Assessment of HIF-1alpha function and identification of a novel degradation mechanism

    Author : Helder André; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF-1alpha and ARNT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE

  5. 3. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1

    Author : Anita Popko-Scibor; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. READ MORE

  6. 4. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Author : Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. READ MORE

  7. 5. SUMO and ubiquitin : the yin and yang of IGF-1R function

    Author : Bita Sehat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor (IGF-1R) plays pivotal roles in cancer. READ MORE