Search for dissertations about: "thesis on thalassemia"

Found 4 swedish dissertations containing the words thesis on thalassemia.

  1. 1. Studies of Thai blood group and platelet polymorphism. Implications for malaria susceptibility

    University dissertation from Lund University, Faculty of Medicine

    Author : Philaiphon Jongruamklang; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thai; Blood group polymorphism; Human platelet antigens; Malaria susceptibility; Plasmodium falciparum;

    Abstract : The objectives of the thesis were to seek a better understanding of polymorphic RBC surface molecules in the Thai, and to investigate the role of certain blood groups in malarial invasion. MALDI-TOF MS was employed in Study I as an efficient method for genotyping to establish the common blood group and platelet antigen genotypes of 396 blood donors. READ MORE

  2. 2. Oligomerization of human and bacterial frataxin : Structural and functional studies

    University dissertation from Lund University, Faculty of Science, Department of Chemistry, Division of Biochemistry and Structural Biology

    Author : Mostafa Abdalkhalik; [2017-02]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Abstract : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. READ MORE

  3. 3. Optimization of the Formulation and Design of Oligonucleotide-based Pharmaceuticals for the Purpose of Gene Therapy

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Eman M. Zaghloul; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. READ MORE

  4. 4. Relation of nutritional status, immunity, hemoglobinopathy and falciparum malaria infection

    University dissertation from Stockholm : Wenner-Grens institut för experimentell biologi

    Author : Alice Nyakeriga; Stockholms universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Iron deficiency; nutrition; anthropometric indexes; malaria; hemoglobinopathies; immunity; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi;

    Abstract : The interaction between nutritional status and malaria disease is complex and often controversial. Nutritional deficiencies (macro- or micro-nutrient) are thought to lead to malnutrition with subsequent susceptibility to malaria infection. On the other hand severe malaria or repeated malaria infections lead to malnutrition. READ MORE