Search for dissertations about: "thesis topics on oncology"
Showing result 1 - 5 of 14 swedish dissertations containing the words thesis topics on oncology.
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1. Helical tomotherapy for total marrow and total skin irradiation : Optimisation, verification, and clinical results
Abstract : In modern cancer therapy, radiotherapy (RT) is a vital part of most treatments. Most RT treatments in Sweden are performed using intensity-modulated radiotherapy (IMRT) with fixed or dynamic arc delivery. The dose gradients outside the target are steep, the margins are small, and the treatment delivery is complicated. READ MORE
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2. Radiation Oncology Data and Modelling Side Effects after Radiation Therapy
Abstract : Although modern radiation therapy techniques have the ability to conform the dose distribution of ionizing radiation tightly around the volume to be treated, unwanted irradiation to surrounding organs remains a problem. The probability of a side effect arising in the normal tissue of a patient after radiation therapy can be modelled by sigmoid mathematical functions known as normal tissue complication probability (NTCP) models. READ MORE
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3. Imaging diffusional variance by MRI [public] : The role of tensor-valued diffusion encoding and tissue heterogeneity
Abstract : Diffusion MRI provides a non-invasive probe of tissue microstructure. We recently proposed a novel method for diffusion-weighted imaging, so-called q-space trajectory encoding, that facilitates tensor-valued diffusion encoding. READ MORE
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4. Functional and Molecular Characterization of BRCA1 and BRCA2 Associated Breast Cancer
Abstract : This doctoral dissertation is based on five appended papers primarily concerned with three main topics, namely: the functional characterization of specific and clinically relevant perturbations found in BRCA1 ? one of the major breast cancer susceptibility genes; the use of microarray technologies for molecular characterization of hereditary breast tumor samples from a genomic perspective; and finally, the development of software to address some of the logistical problems of data analysis and management that arise when utilizing microarrays. Results obtained from the work presented herein demonstrate the following: that transcription az says can aid in the characterization of C-terminal missense mutations but that it may not be possible to unambiguously characterize variants with a yeast-based assay alone; that a naturally occurring C-terminal germline mutation in BRCA1 encodes a protein with apparent temperature-dependant functional properties; that open-source software can provide comprehensive solutions to meet data management needs of microarray experimenters; that BRCA1 and BRCA2 associated breast tumors exhibit markedly different copy number aberrations when compared to each other as well as to sporadic tumors; and that gene expression profiling in BRCA1 and BRCA2 associated breast tumors reveals specific gene expression patterns. READ MORE
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5. From single-molecule sensing to extracellular vesicles in glioma cells under stress
Abstract : This thesis describes the work I conducted in two different areas, namely biomolecular sensing and quantitative cell biology. The work in the former area was focused on the optimization of plasmonic metamaterials for sensing applications, and in the latter on the characterization of extracellular vesicles released by glioblastoma cells under stress conditions. READ MORE
