Search for dissertations about: "thesis topics on oncology"

Showing result 1 - 5 of 11 swedish dissertations containing the words thesis topics on oncology.

  1. 1. Helical tomotherapy for total marrow and total skin irradiation : Optimisation, verification, and clinical results

    Author : André Änghede Haraldsson; Lund Medicinsk strålningsfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; ALL; Leukemia; radiotherapy; hematology; Oncology; Leukemia; radiotherapy; Tomotherapy; Oncology; ALL;

    Abstract : In modern cancer therapy, radiotherapy (RT) is a vital part of most treatments. Most RT treatments in Sweden are performed using intensity-modulated radiotherapy (IMRT) with fixed or dynamic arc delivery. The dose gradients outside the target are steep, the margins are small, and the treatment delivery is complicated. READ MORE

  2. 2. Imaging diffusional variance by MRI [public] : The role of tensor-valued diffusion encoding and tissue heterogeneity

    Author : Filip Szczepankiewicz; Lund Medicinsk strålningsfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Abstract : Diffusion MRI provides a non-invasive probe of tissue microstructure. We recently proposed a novel method for diffusion-weighted imaging, so-called q-space trajectory encoding, that facilitates tensor-valued diffusion encoding. READ MORE

  3. 3. Functional and Molecular Characterization of BRCA1 and BRCA2 Associated Breast Cancer

    Author : Johan Vallon-Christersson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; Cytology; BioArray Software Environment; BASE; Software; Open-source; Copy number; Gene expression; Microarray; BRCA2; BRCA1; Breast cancer; Hereditary cancer; oncology;

    Abstract : This doctoral dissertation is based on five appended papers primarily concerned with three main topics, namely: the functional characterization of specific and clinically relevant perturbations found in BRCA1 ? one of the major breast cancer susceptibility genes; the use of microarray technologies for molecular characterization of hereditary breast tumor samples from a genomic perspective; and finally, the development of software to address some of the logistical problems of data analysis and management that arise when utilizing microarrays. Results obtained from the work presented herein demonstrate the following: that transcription az says can aid in the characterization of C-terminal missense mutations but that it may not be possible to unambiguously characterize variants with a yeast-based assay alone; that a naturally occurring C-terminal germline mutation in BRCA1 encodes a protein with apparent temperature-dependant functional properties; that open-source software can provide comprehensive solutions to meet data management needs of microarray experimenters; that BRCA1 and BRCA2 associated breast tumors exhibit markedly different copy number aberrations when compared to each other as well as to sporadic tumors; and that gene expression profiling in BRCA1 and BRCA2 associated breast tumors reveals specific gene expression patterns. READ MORE

  4. 4. Dosimetric effects of breathing motion in radiotherapy

    Author : Anneli Edvardsson; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; radiotherapy; breathing motion; DIBH; interplay effects; VMAT; proton therapy; breast cancer; Hodgkin’s lymphoma; liver; dosimetry; treatment planning; medical physics;

    Abstract : The goal of radiotherapy is to deliver a homogeneous high dose of radiation to a tumour while minimising the dose to the surrounding healthy tissue. To achieve this, increasingly advanced treatment techniques, such as volumetric modulated arc therapy (VMAT) and proton therapy, have been developed. READ MORE

  5. 5. Relative biological effectiveness in proton therapy: accounting for variability and uncertainties

    Author : Jakob Ödén; Iuliana Toma-Dasu; Kjell Eriksson; Radhe Mohan; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proton therapy; relative biological effectiveness; linear energy transfer; proton track-end optimisation; radiation-induced toxicity; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : Radiation therapy is widely used for treatments of malignant diseases. The search for the optimal radiation treatment approach for a specific case is a complex task, ultimately seeking to maximise the tumour control probability (TCP) while minimising the normal tissue complication probability (NTCP). READ MORE