Search for dissertations about: "thesis tuberculosis isoniazid"

Showing result 1 - 5 of 23 swedish dissertations containing the words thesis tuberculosis isoniazid.

2. 1. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

   Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

4. 2. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs

   Author : Chunli Chen; Ulrika Simonsson; Mats Karlsson; Sebastian Wicha; Bernd Meibohm; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculosis; pharmacokinetics; pharmacodynamics; pharmacometrics; the Multistate Tuberculosis Pharmacometric model; the General Pharmacodynamic Interaction model; optimized design; rifampicin; isoniazid; ethambutol; pyrazinamide; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. READ MORE

5. 3. General awareness of HIV, tuberculosis co-infections and the quality of life among patients with HIV in Xinjiang, in western China

   Author : Rena Maimaiti; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; tuberculosis; quality of life; prevention; pregnancy; isoniazid prophylaxis; treatment outcome;

   Abstract : Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are major public health problems, particularly in low and middle-income countries. China has the second-highest number of TB cases per year in the world. The overall aims of my thesis were to analyze awareness of HIV and identify measures for its prevention. READ MORE

6. 4. Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV

   Author : Jesper Sundell; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; HIV; Pharmacokinetics; Pharmacogenetics; LC-MS MS; Individualized therapy;

   Abstract : Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for tuberculosis consists of rifampicin, isoniazid, pyrazinamide and ethambutol. READ MORE

7. 5. Molecular epidemiology of tuberculosis

   Author : Ramona Groenheit; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy tuberculosis may be a mortal disease. READ MORE