Search for dissertations about: "thrombin inhibitor"
Showing result 11 - 15 of 47 swedish dissertations containing the words thrombin inhibitor.
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11. Venous thromboembolism. Aspects on risk factors, diagnostic tools and treatment with thrombin inhibition
Abstract : Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease. The aims of the present thesis were to investigate Factor V Leiden and prothrombin G20210A mutations as potential risk factors for VTE during and after major surgery, to compare different D-dimer assays and evaluate their usefulness in the diagnosis of DVT, to investigate clinical effects, safety and pharmacokinetic properties of an oral thrombin inhibitor (ximelagatran) when treating VTE and finally to investigate the usefulness of coagulation assays (APTT and PT) during treatment with thrombin inhibition. READ MORE
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12. Experimental studies on thrombin inhibition in acute- and chronic models of vessel wall injury
Abstract : Background: The number of percutaneous coronary interventions (PCI) performed worldwide has increased dramatically during the last decade. Complication rates have decreased over time, however the restenosis phenomenon remains an unsolved issue. Thrombin is the key regulator in the pro-coagulant state following PCI. READ MORE
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13. Inflammation and Coagulation Activity in Unstable Coronary Artery Disease and the Influences of Thrombin Inhibition
Abstract : In patients with unstable coronary artery disease, this study evaluated the degree of inflammation and coagulation activity, relations to myocardial cell damage, prognosis, and influences of randomisation to 72 h infusion with three different doses of inogatran, a direct thrombin inhibitor (n=904), or unfractionated heparin (n=305). Anticoagulant treatment effects were evaluated with aPT time. READ MORE
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14. Experimental studies on thrombosis and thrombolysis : With special reference to importance of lys-plasminogen, active site thrombin inhibitors and stable fish oil
Abstract : Dissolution and prevention of thrombus in the atherosclerotic coronary artery have become an important part of treatment therapy of acute myocardial infarction. However, the currently most effective thrombolytic agent, recombinant tissue-type plasminogen activator (rt-PA), only elicits 80% recanalization of thrombotically occluded coronary arteries and early occlusion occurs in about 40% of successfullyrecanalized vessels. READ MORE
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15. Regulation of Tissue Factor and Coagulation Activity : Translation Studies with Focus on Platelet-Monocyte Aggregates and Patients with Acute Coronary Syndrome
Abstract : Myocardial infarction (MI) is often caused by a disruption of an atherosclerotic plaque with activation of coagulation, platelets and inflammation. The aims were; to investigate whether the oral direct thrombin inhibitor, ximelagatran affected markers for coagulation, platelet and inflammation in a patient cohort with recent MI and if the coagulation markers could identify patients with increased risk of new ischemic events; to evaluate some of the mechanisms involved in formation of platelet-monocyte aggregates (PMAs). READ MORE