Search for dissertations about: "thrombin."

Showing result 1 - 5 of 135 swedish dissertations containing the word thrombin..

2. 1. Novel actions of thrombin-derived host defense peptides

   Author : Finja Hansen; Lund Dermatologi och venereologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defense peptides; Thrombin; Monocytes Macrophages; Gram-negative bacteria; LPS; TLR; Phagocytosis; Inflammation; Endocytosis;

   Abstract : Thrombin-derived C-terminal peptides (TCPs) constitute a novel class of immunomodulatory host defense peptides, generated during infection and inflammation. Previous investigations have shown that TCPs of 2-3 kDa inhibit pro-inflammatory immune responses in vitro and in vivo, but their mode of action remained unclear. READ MORE

4. 2. Thrombin generation in different cohorts : Evaluation of the haemostatic potential

   Author : Roza Chaireti; Tomas Lindahl; Elvar Theodorsson; Sven Almer; Per Morten Sandset; Linköpings universitet; []
   Keywords : ;

   Abstract : The aim of this thesis is to evaluate thrombin generation in patients with thrombophilia (Paper I), in patients with venous thromboembolism (Paper II), in healthy women during the menstrual cycle (Paper III), in patients with liver disease (Paper IV) and in patients with mild deficiency of factor VII (Paper V).For this purpose, thrombin generation was measured in platelet poor plasma by the calibrated automated thrombogram (CAT®) assay. READ MORE

5. 3. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

   Author : Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

   Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE

6. 4. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

   Author : Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

   Abstract : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. READ MORE

7. 5. Novel Aspects of the Coagulation System in Host Defence

   Author : Praveen Papareddy; Lund Dermatologi och venereologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defence peptides; Coagulation system; Sepsis; Thrombin; TFPI-1; TFPI-2; HCII;

   Abstract : Bacterial infections are a major global threat to public health and sepsis is a major cause of morbidity and mortality. Sepsis incidence is rising, with supportive treatments and antibiotics being the main treatment possibilities. READ MORE