Search for dissertations about: "thrombocytopenia thesis"

Showing result 1 - 5 of 35 swedish dissertations containing the words thrombocytopenia thesis.

2. 1. Aspects of Complement Activation in Thrombocytopenic Disorders

   Author : Alexander Åkesson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thrombocytopenia; Complement activation; Complement dysregulation; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome; Platelet transfusion refractoriness;

   Abstract : The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. READ MORE

4. 2. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention

   Author : Tobias Svensson; Honar Cherif; Martin Höglund; Jan Sjölin; Christine Wennerås; Uppsala universitet; []
   Keywords : Chronic lymphocytic leukemia; Immunodeficiency; Hypogammaglobulinemia; IgG subclass; Pneumococci; Pneumococcal vaccine; Polysaccharide vaccine; Protein-conjugate vaccine; Aspergillosis; Bronchoalveolar lavage; Invasive fungal disease; Pneumocystis jirovecii pneumonia; Myelodysplastic syndrome; Azacitidine; Eltrombopag; Thrombocytopenia; Thrombopoietin receptor; Oncology; Onkologi;

   Abstract : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. READ MORE

5. 3. Streptococcus pyogenes - a manipulator of human defences

   Author : Fredrik Kahn; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pyogenes; M protein; neutrophils; platelets; platelet-neutrophil complexes; fibrinogen; IgG; abscess; venous thrombosis; heparin binding protein; thrombocytopenia;

   Abstract : Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. READ MORE

6. 4. Model-Based Optimization of Clinical Trial Designs

   Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

7. 5. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

   Author : Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. READ MORE