Search for dissertations about: "thrombocytopenia"
Showing result 6 - 10 of 35 swedish dissertations containing the word thrombocytopenia.
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6. Model-Based Optimization of Clinical Trial Designs
Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE
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7. Epidemiological perspective of chronic immune thrombocytopenia
Abstract : This thesis deals with different aspects of immune thrombocytopenia disease (ITP), what happens before diagnosis, characteristics of patients at treatment start and outcomes potentially related to the disease and treatment, such as thrombosis and cancer. In study one we investigate the risk of infections prior to the diagnosis of ITP. READ MORE
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8. Fetal and neonatal alloimmune thrombocytopenia : immunological mechanisms and clinical consequences
Abstract : Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition that may occur in connection with pregnancy, when maternal antibodies directed against paternally inherited platelet antigens cross the placenta and mediate thrombocytopenia in the fetus and neonate. FNAIT puts the fetus at risk of severe bleedings, with an intracranial hemorrhage being the most feared outcome. READ MORE
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9. Neonatal thrombocytopenia : from bleeding risk to new therapies on the horizon
Abstract : Background: Thrombocytopenia is common in the Neonatal Intensive Care Unit and if severe, it is treated with platelet transfusions to prevent bleeding. Previous studies found a weak correlation between thrombocytopenia and incidence of bleeding. READ MORE
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10. Preclinical and Clinical Development of the Novel Cyanoguanidine CHS 828 for Cancer Treatment
Abstract : CHS 828 is a cyanoguanidine with anti-tumour properties which has shown promising effects in several preclinical models. This thesis describes both preclinical and clinical studies aiming to investigate disease specific activity, clinical tolerability and efficacy of CHS 828. READ MORE