Search for dissertations about: "thymine analogue"

Found 3 swedish dissertations containing the words thymine analogue.

  1. 1. DNA and RNA base analogue FRET - from fluorophore design to biochemical applications

    Author : Moa Sandberg Wranne; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; adenine analogue; Fluorescent base analogue; FRET; thymine analogue; netropsin; fluorescence; DNA; RNA; Z-RNA;

    Abstract : This thesis focuses on the development and use of fluorescent base analogues (FBAs). They are important tools in research concerning nucleic acids structure, dynamics and interactions. READ MORE

  2. 2. Expanding the alphabet of fluorescent nucleic acid base analogues: Characterization of new members

    Author : Anke Dierckx; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fluorescent adenine analogue; fluorescent DNA base analogue; duplex stability; Fluorescence quantum yield; circular dichroism; B-DNA;

    Abstract : Fluorescence has proven to be a powerful tool for studying structure, dynamics and interactions of biomolecules such as proteins, RNA and DNA. However, since the natural DNA/RNA nucleobases are virtually non-fluorescent, there is a need for developing fluorescent nucleic acid markers. READ MORE

  3. 3. A biophysical study of nucleic acid interactions with analogues and drugs

    Author : Ulrica Sehlstedt; Donald M Crothers; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nucleic acids; binding modes; polarised light spectroscopy; linear dichroism; NMR; triple helix; base-pair breathing dynamics; DAPI; porphyrins; quinoxaline derivatives; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. READ MORE