Search for dissertations about: "thymocytes"

Showing result 1 - 5 of 40 swedish dissertations containing the word thymocytes.

  2. 1. Dissecting the role of micro-RNAs in diabetes

    Author : Caroline Bolmeson; Create Health; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  4. 2. Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in G?i2-deficient and DSS-induced Colitis as well as in IBD patients

    Author : Kristina Elgbratt; Göteborgs universitet; []
    Keywords : Inflammatory bowel diseaseInflammatory bowel disease; G?i2- - mice; dextran sodium sulfate; thymocytes; T cell receptor excision circles TRECs ; resent thymic emigrants;

    Abstract : Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in G?i2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, G?teborg University, G?teborg Sweden Inflammatory Bowel Disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract, comprising ulcerative colitis and Crohn?s disease. READ MORE

  5. 3. Modulation of Autoimmunity by Linomide treatment or interference with costimulation

    Author : Annamaria C Tellander; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; collagen-induced arthritis; CD28; CD40; antigen presenting cells; Linomide; thymocytes; cancerology; Cytologi; onkologi; cancer;

    Abstract : Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease. We have approached the cellular and molecular mechanism of Linomide by investigating its effect on thymocyte development and its capacity to modulate the expression of activation markers on antigen presenting cells (APCs). READ MORE

  6. 4. On the Role of Polyamines in Apoptosis

    Author : Cecilia Hegardt; Bröstcancer-genetik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SSAT; DENSPM; spermine; polyamines; mitochondrial membrane potential; cytochrome c; caspase; flow cytometry; Jurkat cells; mouse thymocytes; thymus in vivo; programmed cell death; Dexamethasone-induced apoptosis; Fas-induced apoptosis; AdoMetDC; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; Clinical biology; Klinisk biologi; Animal physiology; Djurfysiologi;

    Abstract : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. READ MORE

  7. 5. Glucocorticoids in the development and homeostasis of T lymphocytes

    Author : Ahmad Pazirandeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate the effects of physiological nonstressed levels of endogenous GCs on the development, differentiation and homeostasis of T lymphocytes. READ MORE