Search for dissertations about: "thymus"

Showing result 1 - 5 of 89 swedish dissertations containing the word thymus.

  1. 1. Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus

    University dissertation from Mucosal Immunology, EMV, Lund University

    Author : Katarzyna Sitnik; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; mesenchymal cells; retinoic acid; thymic epithelial cells;

    Abstract : T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical and medullary regions that are composed of epithelial and mesenchymal stromal elements. READ MORE

  2. 2. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    University dissertation from Mucosal Immunology, EMV, Lund University

    Author : Kajsa Wing; Göteborgs universitet.; Gothenburg University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Abstract : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. READ MORE

  3. 3. Generation of lymphocytes in the thymus : a study of morphologic, antigenic and functional development of lymphocytes in embryonic thymus organ cultures

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Roger Juhlin; Uppsala universitet.; [1977]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 4. Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christina Lundqvist; Göteborgs universitet.; Gothenburg University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; thymectomy; TCR; B cells; APC; Hassall s corpuscles; AIRE;

    Abstract : This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a thorough selection process in which the TCR is tested for functionality and autoreactivity. READ MORE

  5. 5. Characteristics and functions of thymic exosomes in human and mouse

    University dissertation from Göteborg : Kompendiet

    Author : Gabriel Skogberg; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosome; thymus; tissue-restricted antigen; Aire; Down syndrome;

    Abstract : Thymocytes develop in the thymus to become a functional pool of T-cells in the periphery. To achieve this, the thymocytes go through several steps of maturation and selection within the thymus. READ MORE