Search for dissertations about: "thyroid cells"

Showing result 1 - 5 of 101 swedish dissertations containing the words thyroid cells.

  2. 1. Regulation of E-cadherin mediated adhesion in thyroid epithelial cells

    Author : Fredrik Larsson; Göteborgs universitet; []
    Keywords : thyroid; adherens junction; E-cadherin; thyrotropin; cAMP; PKA; Epac; IQGAP;

    Abstract : Cell adhesion is one of multicellular organisms most fundamental features. Cells connect to each other by transmembrane proteins arranged in junction complexes. READ MORE

  4. 2. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Author : Madeleine Nordén; Göteborgs universitet; []
    Keywords : thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Abstract : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. READ MORE

  5. 3. Molecular regulation of thyroid development. New mechanisms of normal and defective morphogenesis

    Author : Henrik Fagman; Göteborgs universitet; []
    Keywords : thyroid; congenital hypothyroidism; thyroid dysgenesis; cadherins; pharyngeal arch arteries; Shh; Tbx1;

    Abstract : Congenital hypothyroidism (CH) is untreated a major cause of mental retardation. The majority of cases are due to malformations of the gland (dysgenesis). Little is known of molecular mechanisms regulating thyroid morphogenesis. READ MORE

  6. 4. In vitro radiobiological effects of 131I on thyroid cells: towards a mechanistic understanding of thyroid stunning

    Author : Nirmal Bhogal; Göteborgs universitet; []
    Keywords : thyroid; radioiodide; stunning; 131I; stress response; DNA damage; Chk2; H2AX; micronuclei; cell cycle;

    Abstract : .... READ MORE

  7. 5. Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals

    Author : Jessica Westerlund; Göteborgs universitet; []
    Keywords : thyroid; congenital hypothyroidism; dysgenesis; Tbx1; Shh; Isl1; Foxa2; C-cells;

    Abstract : Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. READ MORE