Search for dissertations about: "thyroid hormone receptor."

Showing result 21 - 25 of 56 swedish dissertations containing the words thyroid hormone receptor..

  2. 21. Gene regulation by nuclear hormone receptors in vivo

    Author : Anethe Mansén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TR? and TR?. These receptors are ligand-modulated transcription factors that activate or repress gene activity. The TR? gene encodes two main splice variants, TR?1 and TR?2. READ MORE

  4. 22. Gene expression profiling in molecular studies of hormone actions

    Author : Nina Ståhlberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Although the link between hormones and their physiological effects have been known for a long time, large pieces are still missing in our understanding of how these extracellular signals induce their effects at the cellular level. Signal transduction studies have gathered plenty of information about hormone signaling, but the complex network of interactions between different hormones, signaling pathways and cell types is still not completely understood. READ MORE

  5. 23. Finding the ligand : retinoid receptor activation in the CNS

    Author : Alexander Mata de Urquiza; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear hormone receptors (NRs) comprise a large family of ligand activated transcription factors, found in vertebrates, arthropods and nematodes. Among the members of the NR family are the receptors for small, lipophilic ligands such as the steroid hormones, vitamins A and D, thyroid hormone oxysterols and bile acids. READ MORE

  6. 24. Adaptability of skeletal muscle to hormone treatment in relation to gender and aging

    Author : Fushun Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skinned muscle fiber; gender; aging; steroid hormone; V0 electrophoresis; MyHC; MyLC; enzymehistochemistry; hyperthyroid rat; thyroid hormone receptor TR deficient TR[alpha]1 - -; TR[beta]- -; and TR[alpha]1- -[beta]- - mice;

    Abstract : The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. In addition, by using mice lacking thyroid hormone receptors (TR[alpha]1 or TR[beta] or TR[alpha]1/[beta]) we tried to improve our understanding of the mechanisms by which thyroid hormone regulates the expression of specific MyHC isoforms via these different nuclear receptors. READ MORE

  7. 25. Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes

    Author : Wanjin Tang; Kjell Wikvall; Maria Norlin; Mats Gåfvels; Uppsala universitet; []
    Keywords : Pharmaceutical biochemistry; CYP27A1; CYP7B1; cholesterol; estrogen; androgen; prostate; glucocorticoid receptor; fetal development; Farmaceutisk biokemi;

    Abstract : CYP27A1 and CYP7B1 are widely expressed in various human tissues and are two key enzymes involved in the pathways for conversion of cholesterol to bile acids. Also, CYP27A1 is involved in bioactivation of vitamin D3 and CYP7B1 plays a role in 7alpha-hydroxylation of dehydroepiandrosterone and other steroids. READ MORE