Search for dissertations about: "thyroid hormone receptor."

Showing result 6 - 10 of 56 swedish dissertations containing the words thyroid hormone receptor..

  2. 6. Expression and function of thyroid hormone receptor alpha 1 in the brain

    Author : Karin Wallis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thyroid hormone is fundamentally important for development and maintenance of adult brain functions and maternal hypothyroxinemia during pregnancy can lead to a severe mental retardation known as endemic cretinism. The first realization that endemic cretinism is caused by iodine deficiency and its association with thyroid hormone was made a century ago; this eventually resulted in dietary supplementation programme, e. READ MORE

  4. 7. Regulation of gene transcription by the thyroid hormone receptors

    Author : Maria Nygård; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Thyroid hormone receptors; T3; cell differentiation; gene regulation; E2F-1; Necdin; TRH; nTRE; RXR; NCoR; XAP-2;

    Abstract : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. READ MORE

  5. 8. Thyroid hormone receptors and the regulation of bone physiology

    Author : Jenny Kindblom; Göteborgs universitet; []
    Keywords : ;

    Abstract : The aim of the studies in this thesis was to investigate the role of thyroid hormone receptors in bone physiology. Thyroid hormone signals through its receptors, the TRs, and has profound effects on bone development and metabolism, as demonstrated in hypo- and hyperthyroidism. READ MORE

  6. 9. Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology

    Author : Maria Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lack of sufficient thyroid hormone during pregnancy and early postnatal development results in profound mental retardation and motor deficits whereas altered thyroid status in the adult is associated with disturbed metabolic homeostasis and impaired cardiac function. Thyroid hormone mediates its effects through the distinct thyroid hormone receptors (TR) TRalpha1 and TRbeta1-2, which are ligand-modulated transcription factors that regulate gene expression both in the presence and absence of hormone. READ MORE

  7. 10. Transcriptional regulation by the thyroid hormone receptor and its viral counterpart : the P75gag-V-erbA oncoprotein

    Author : Gunilla Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Transcriptional regulation; thyroid hormone; TR; P75gag-v-erbA; repression; Avian erythroblastosis virus; response elements; RXR; retinoids.;

    Abstract : Thyroid hormone binds to specific DNA binding receptors (TRs) in the cell nucleus and thus regulates transcription during development and in some pathological disorders. The gene of the viral TR homologue, v-erbA, is one of two oncogenes encoded in the genome of avian erythroblastosis virus (AEV). READ MORE