Search for dissertations about: "tiago"
Showing result 1 - 5 of 14 swedish dissertations containing the word tiago.
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1. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors
Abstract : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. READ MORE
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2. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair
Abstract : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. READ MORE
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3. Structure and Dynamics in Amphiphilic Bilayers: NMR and MD simulation Studies
Abstract : Solid-state nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulations were employed to study molecular structure and dynamics in amphiphilic bilayers. This thesis reports on method development and practical applications to two types of bilayer systems: simple cell membrane models composed of phosphatidylcholine lipids and cholesterol; and liquid crystals composed of ethyleneoxide-based surfactants often used in technological applications and in fundamental studies of amphiphile self-assembly. READ MORE
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4. Nucleic Acids: Innovative Methods for Recovery, Clarification and Purification
Abstract : The importance of nucleic acids in pure form for preparative and analytical perspectives, have increased constantly, demanding the development of new and more efficient methods for their recovery and isolation. This thesis describes a series of different innovative methods for recovery and purification of these biomolecules. READ MORE
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5. Dopamine : a versatile player in development, regeneration and disease
Abstract : The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine hormone secretion. READ MORE