Search for dissertations about: "tight junction proteins"

Showing result 1 - 5 of 34 swedish dissertations containing the words tight junction proteins.

2. 1. Tight juntion in ovarian surface epithelium and epithelial ovarian tumors

   Author : Yihong Zhu; Göteborgs universitet; []
   Keywords : junction; claudin; ovarian surface epithelium; epithelial ovarian tumor; TGF-?1;

   Abstract : Epithelial ovarian cancer originating from ovarian surface epithelium (OSE) is the most lethal type of gynecological cancer among women worldwide. The poor understanding of the cellular and molecular events associated with ovarian carcinogenesis leads to difficulties in early diagnosis and in efficient treatment. READ MORE

4. 2. Cell adhesion proteins in different invasive patterns of colon carcinomas : a morphometric and molecular genetic study

   Author : Victoria Hahn-Strömberg; Lennart Franzén; Richard Palmqvist; Örebro universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; colon carcinoma; growth pattern; tight junction; Complexity Index; cell adhesion; E-cadherin; Beta-catenin; Occludin; Claudin.; Medicine; Medicin; Biomedicin; Biomedicine;

   Abstract : Colorectal carcinoma is the second most common type of cancer in both men and women in Sweden. Cancer of the colon and rectum are often considered together and their ten year survival rate is approximately 50 – 60 % depending on sex and location. READ MORE

5. 3. The Human Spiral Ganglion

   Author : Sven Tylstedt; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; human spiral ganglion; ultrastructural morphology; neural interaction; synaptophysin; connexin; membrane specializations; synapse; gap junction; tight junction; Otorhinolaryngologi; Otorhinolaryngology; Otorhinolaryngologi; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

   Abstract : Our knowledge of the fine structure of the Human Spiral Ganglion (HSG) is still inadequate and new treatment techniques for deafness using electric stimulation, call for further information and studies on the neuronal elements of the human cochlea. This thesis presents results of analyses of human cochlear tissue and specimens obtained during neurosurgical transpetrosal removal of life-threatening meningeomas. READ MORE

6. 4. Genetic variation of tight junction structures in intestinal inflammation

   Author : Elisabeth Norén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The epithelial barrier facing the external environment in the gastrointestinal (GI) tract is comprised of several components, including the tight junction (TJ) structures observed for the first time in 1963. TJ structures, which are multiprotein complexes composed of transmembrane proteins and a diverse spectrum of intracellular components, create a primary barrier to diffusion of ions, solutes, and water and they concomitantly prevent permeation of pro-inflammatory factors, such as pathogens, toxins, and antigens. READ MORE

7. 5. Developmental Aspects of Drug Transport Across the Blood-Brain Barrier

   Author : Jörgen Bengtsson; Margareta Hammarlund-Udenaes; Ann-Cathrin Engwall; Sven Björkman; Elizabeth C.M. de Lange; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; development; active transport; tight junction proteins; microdialysis; recovery; morphine; nitrofurantoin; Bcrp; microarray; real-time PCR; in vitro; in vivo; LC-MS MS; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : The developmental aspect of drug transport across the blood-brain barrier (BBB) was investigated. Microdialysis was used to study unbound morphine BBB transport at different ages in sheep. An in vitro study was performed to find differentially expressed genes in brain capillary-rich fractions of the brain in rats of different ages. READ MORE