Search for dissertations about: "tight junctions"

Showing result 1 - 5 of 44 swedish dissertations containing the words tight junctions.

  2. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Author : Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE

  4. 2. Epithelial barrier dysfunction in ileal Crohn's disease

    Author : Johan Dabrosin-Söderholm; Svante Nordgren; Linköpings universitet; []
    Keywords : acetylsalicylic add; confocal microscopy; Crohn s disease; cytoskeleton; electron microscopy; genetics; human; ileum; inflammatory bowel disease; intestinal absorption; intestinal mucosa; macromolecules; mitochondria; ovalbumin; permeability; sodium caprate; tight junctions; transcytosis; uncoupling agents; Ussing chamber; MEDICINE; MEDICIN;

    Abstract : The study aimed at investigating the intestinal barrier in Crohn's disease, with special reference to epithelial responses to luminal stimuli, and to permeation of proteins.Ileal mucosa from patients undergoing intestinal resection was studied in vitro in Ussing chambers. READ MORE

  5. 3. Cell Contacts and Airway Epithelial Damage in Asthma

    Author : Shahida Shahana; Godfried Roomans; Rolf Odselius; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anatomy; Desmosomes; tight junctions; major basic protein; eosinophil; cytokines; epithelial damage.; Anatomi; Anatomy; Anatomi;

    Abstract : Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells.Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). READ MORE

  6. 4. Mechanisms for and Effects of Airway Epithelial Damage in Asthma

    Author : Anne-Jacqueline Relova; Eythor Björnsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; asthma; airways; cytokines; epithelium; tight junctions; mast cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The airway epithelium plays a crucial role in protecting the underlying connective tissue (CT) from noxious agents. Damage and shedding of the epithelium are observed in the airways of asthma, cystic fibrosis and rhinitis patients. READ MORE

  7. 5. Coeliac Disease in Childhood : On the Intestinal Mucosa and the Use of Oats

    Author : Elisabet Hollén; Karl-Eric Magnusson; Marie-Louise Hammarström; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiaki; havre; avenin; anti-aveninantikroppar; NO; tight junctions; occludin; claudin; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : Celiaki, eller glutenintolerans, är en av våra vanligaste kroniska sjukdomar i barnaåren. Sjukdomen orsakar en kraftig inflammation i tunntarmens slemhinna efter intag av glutenhaltig föda hos personer med ärftlig benägenhet att utveckla celiaki. En frisk tarm är kraftigt veckad för att öka ytan för upptag av näringsämnen. READ MORE