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Showing result 1 - 5 of 124 swedish dissertations matching the above criteria.

2. 1. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

   Author : Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
   Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

   Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

4. 2. Mechanisms and time course of cell death in embryonic nigral tissue and intrastriatal transplants

   Author : Mia Emgård; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothermia; resveratrol; free radicals; ultrastructure; electron microscopy; mesencephalic; transplantation; rat; Parkinson s disease; dopamine; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and severely affects about one in a hundred persons over the age of fifty years. In PD, there is a reduced striatal concentration of the neurotransmittor dopamine, mainly caused by a degeneration of the dopaminergic neurons in the substantia nigra. READ MORE

5. 3. Acute and long-term effects of pulmonary embolism on heart function and lung circulation

   Author : Ary Ribeiro; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Pulmonary embolism; pulmonary heart disease; follow-up studies; nuclear medicine; perfusion; echocardiography; ventricular function; statistics; time-course;

   Abstract : Objectives: To describe the course over time of pulmonary artery systolic pressure (PAsP) and right ventricle (RV) function assessed with echocardiography-Doppler (E-D) and extent of perfusion defects (PDf) on lung scintigraphy (LS) and to identify patients at increased risk for death or for chronic pulmonary hypertension (PH), after pulmonary embolism (PE). Design: Prospective follow-up studies with cross-sectional analyses. READ MORE

6. 4. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

   Author : Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE

7. 5. Regulation of digestive organ. An experimental study on the role of CCK, Bile and EGF

   Author : Bodil Ohlsson; Internmedicin - epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; trophic effects; total parenteral nutrition; salivary glands; pancreaticobiliary diversion; pancreas; liver; intestinal mucosa; epidermal growth factor; cholecystokinin; biliodigestive shunt; Bile; bilary tract; serology; transplantation; Immunologi; serologi; Gastro-enterology; Gastroenterologi;

   Abstract : Cholecystokinin (CCK) is known to exert secretory and trophic effects on the pancreas. Its release from the intestinal mucosa is regulated by pancresic proteases in the small intestine. However, knowledge about the type of responding exocrine cells and the time course of events during stimulation with CCK is lacking. READ MORE