Search for dissertations about: "time-of-flight secondary ion mass spectrometry"

Showing result 1 - 5 of 36 swedish dissertations containing the words time-of-flight secondary ion mass spectrometry.

2. 1. Imaging of lipids and proteins in Alzheimer's disease using Time-of-Flight Secondary Ion Mass Spectrometry

   Author : Louise M Carlred; Chalmers University of Technology; []
   Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; QCM-D; fluorescence microscopy; ToF-SIMS; Amyloid-β; immunohistochemistry; Sulfatides; antibodies; liposomes; Alzheimer’s disease; Cholesterol;

   Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the formation of senile plaques. These plaques, which consist of aggregations of a peptide called amyloid-β, are deposited in-between the nerve cells in the brain, where they disrupt the signaling processes. READ MORE

4. 2. Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome

   Author : Amelie Botling Taube; Jonas Bergquist; Albert Alm; Eva Larsson; Hannu Uusitalo; Uppsala universitet; []
   Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseduoexfoliation syndrome; PEX; aqueous humor; cataract; cataract surgery; lens capsule; proteomics; mass spectrometry; MS; MALDI TOF MS MS; quantitative proteomics; iTRAQ; dimethyl labeling; imaging mass spectrometry; IMS; time of flight secondary ion mass spectrometry; TOF-SIMS; crystallin; epidemiology; risk factor; Ophtalmology; Oftalmiatrik;

   Abstract : Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. READ MORE

5. 3. Development and Evaluation of Preparation Methods for the Analysis of Cell Membranes Using Time-of-Flight Secondary Ion Mass Spectrometry

   Author : Jakob Malm; Chalmers University of Technology; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; salt; cryofixation; TOF-SIMS; supported phospholipid bilayer; freeze drying; vacuum; cells; POPC; glutaraldehyde;

   Abstract : The aim of this work was to evaluate and develop methods for preparing dry samples for TOF-SIMS analysis of cell membranes. For correct interpretation of the analysis data, an understanding of the effects that the preparation method has on the morphology and chemical structure of the sample must first be obtained. READ MORE

6. 4. Mass spectrometry of biopolymers based on ion-induced desorption

   Author : Roman Alexandrovich Zubarev; Uppsala universitet; []
   Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Strålningsvetenskap; Radiation biology; Strålningsbiologi; Ion Physics; jonfysik;

   Abstract : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. READ MORE

7. 5. Analysis of phospholipids in cellular membranes with LC and imaging mass spectrometry

   Author : Ingela Lanekoff; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Keywords : Mass spectrometry; TOF-SIMS; Phospholipid; Cells; Anammox;

   Abstract : Imaging mass spectrometry enables the creation of molecule specific images from the surface of a solid sample in vacuum. To solve the issue of bringing single cells into vacuum without altering their native distribution of molecules, a freeze fracture device that fits the time of flight secondary ion mass spectrometry (TOF-SIMS) IV instrument has been developed. READ MORE