Search for dissertations about: "tissue factor pathway inhibitor"

Showing result 16 - 20 of 45 swedish dissertations containing the words tissue factor pathway inhibitor.

  2. 16. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma

    Author : Jonas Sjölund; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; differentiation; clear cell renal cell carcinoma; neuroblastoma; TGF-beta; migration; γ-secretase; valproic acid; cancer; Notch; ERK; von Hippel-Lindau; hypoxia;

    Abstract : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. READ MORE

  4. 17. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways

    Author : Magnus J. Fredriksson; Georg Breier; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Abstract : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. READ MORE

  5. 18. Targeting bacterial infections by using immunomodulatory host defence peptides and proteins

    Author : Martina Kalle; Lund Dermatologi och venereologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host dfence peptides; Sepsis; Immunomodulation; Heparin cofactor II;

    Abstract : Bacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. READ MORE

  6. 19. Caenorhabditis elegans as a model to elucidate host-pathogen interactions for human bacterial pathogens

    Author : Xiao Hui Sem; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The soil nematode Caenorhabditis elegans is a popular host utilized to model bacterial virulence and microbial pathogenesis in vivo. This thesis explores the use of C. elegans for the study of host-pathogen interactions for two Gram-negative bacteria, Burkholderia thailandensis and Salmonella enterica. READ MORE

  7. 20. TNFalpha expression in monocytes/macrophages

    Author : Karolina Andersson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Protein kinase; Macrophage; TNF;

    Abstract : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). READ MORE