Search for dissertations about: "tissue image analysis"

Showing result 21 - 25 of 286 swedish dissertations containing the words tissue image analysis.

  2. 21. Making Visible the Proximity Between Proteins

    Author : Carl-Magnus Clausson; Ola Söderberg; Jens Coorssen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Proximity ligation assay; In situ PLA; rolling circle amplification; protein interaction; protein-protein interaction; in situ; single cell; single molecule; protein complex; antibody; cancer; tissue section; microscopy; image analysis; system biology; multiplex; dynamic range; methods development; systems biology; Molekylär medicin; Molecular Medicine;

    Abstract : Genomic DNA is the template of life - the entity which is characterized by a self-sustaining anatomical development, regulated signaling processes, the ability to reproduce and to respond to stimuli. Through what is classically known as the central dogma, the genome is transcribed into mRNA, which in turn is translated into proteins. READ MORE

  4. 22. Antibody-based Profiling of Expression Patterns using Cell and Tissue Microarrays

    Author : Sara Strömberg; Fredrik Ponten; Joakim Lundeberg; Anna Asplund; Stephen Hewitt; Uppsala universitet; []
    Keywords : Pathology; antibody-based proteomics; tissue microarray; cell line; immunohistochemistry; melanocytes; image analysis; biomarker; Patologi;

    Abstract : In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell lines, a cell microarray (CMA) was developed, facilitating antibody-based protein profiling of cell lines using immunohistochemistry (IHC). READ MORE

  5. 23. Super resolution optical imaging – image analysis, multicolor development and biological applications

    Author : Daniel Rönnlund; Jerker Widengren; Christian Eggeling; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Stimulated emission depletion STED microscopy; nanoscopy; multicolor; image analysis; diagnostics; cancer; metastasis; Biological Physics; Biologisk fysik;

    Abstract : This thesis focuses on super resolution STED optical imaging. STED provides a wealth of new informational content to the acquired images by using stimulated emission to surpass the diffraction limit in optical fluorescence microscopy. READ MORE

  6. 24. Algorithms for Applied Digital Image Cytometry

    Author : Carolina Wählby; Ewert Bengtsson; Stephen Lockett; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bildanalys; Bildanalys; Image analysis; Bildanalys;

    Abstract : Image analysis can provide genetic as well as protein level information from fluorescence stained fixed or living cells without loosing tissue morphology. Analysis of spatial, spectral, and temporal distribution of fluorescence can reveal important information on the single cell level. READ MORE

  7. 25. Development of new MRl-based analysis methods for improved diagnosis of low back pain patients

    Author : Christian Waldenberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; annular fissure; bone marrow lesion; image analysis; intervertebral disc; intervertebral disc degeneration; low back pain; machine learning; radiomics; texture analysis;

    Abstract : BACKGROUND Low back pain (LBP) is the leading cause of disability worldwide, where three of four individuals experience back pain at some point in their lives. The pathophysiological background of LBP is probably multifactorial, where bone marrow damage, tissue changes in the vertebral endplates, and intervertebral disc (IVD) degeneration have been recognized as tissue changes linked to pain. READ MORE