Search for dissertations about: "tissue inhibitor of metalloproteinases TIMP"

Showing result 1 - 5 of 17 swedish dissertations containing the words tissue inhibitor of metalloproteinases TIMP.

  2. 1. Towards surgical use of matrix metalloproteinase biology

    Author : Björn Pasternak; Per Aspenberg; Pentti Tengvall; Yrjö T Konttinen; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; Orthopaedics; Ortopedi;

    Abstract : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. READ MORE

  4. 2. Matrix metalloproteinase-26 (MMP-26) and Tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium

    Author : Radovan Pilka; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Obstetrics; gynaecology; Cytologi; onkologi; cancerology; secretion; Biology; Biologi; Cytology; oncology; implantation; human; endometrium; mRNA; MMP-26; TIMP-4; reproduktion; andrologi; gynekologi; Obstetrik; sexuality; reproduction; sexualitet; andrology;

    Abstract : The aim of the thesis was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium. Most importantnly, both these molecules may be ivolved in the implantation process. Trophoblast tissue from human as well as mouse embryos produces pro-MMP-9. READ MORE

  5. 3. Human ovulation. Studies on collagens, gelatinases and tissue inhibitors of metalloproteinases

    Author : Anna Karin Lind; Göteborgs universitet; []
    Keywords : ovulation; ovary; human; follicle; collagen; MMP and TIMP;

    Abstract : Ovulation is a highly regulated process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of a fertilizable oocyte. This unique biological process is initiated by the LH-surge, which induces major vascular changes and remodelling of the extracellular matrix (ECM) in and around the follicle. READ MORE

  6. 4. Structure and function of MMP-2 and its inhibitor TIMP-2

    Author : Ari Tuuttila; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Metalloproteinases; MMP-2; TIMP-2; extracellular matrix; crystallography; protein structure;

    Abstract : Animal cells secrete various enzymes capable of degrading the extracellular matrix. One of the most studied groups of these are the matrix metalloproteinases (MMPs). This group of zinc containing endopeptidases consists at present of 26 members and this number is still increasing. READ MORE

  7. 5. The Prognostic and Treatment Predictive Value of Proliferation and TIMP-1 in Breast Cancer

    Author : Marie Klintman; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; predictive marker; resistance; prognostic factor; proliferation; prospective; TIMP-1; Ki67; S-phase; MAI; PPH3; cyclin B1; cyclin A; node-negative; validation;

    Abstract : Breast cancer is the most common tumour form and the second leading cause of death in solid tumours in women in the Western world. Despite improvements in the treatment, a considerable number of patients will relapse and die from their breast cancer. READ MORE