Search for dissertations about: "tissue plasminogen activator"

Showing result 6 - 10 of 91 swedish dissertations containing the words tissue plasminogen activator.

  2. 6. Endogenous tissue-type plasminogen activator andendothelial function in vivo. A clinical perspective

    Author : Thorarinn Gudnason; Göteborgs universitet; []
    Keywords : tissue-type plasminogen activator; endothelial function; age; vasodilation; chronic heart failure; coronary artery disease; local regulation; perfused-forearm model;

    Abstract : Endogenous fibrinolysis is initiated by the glycoprotein tissue-type plasminogen activator (tPA), which is released from the vascular endothelium. Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of tPA. READ MORE

  4. 7. Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements

    Author : Peter Hägglöf; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; PAI-1 serpin RCL complex formation DDEM Intramolecular distance; Biomedicin; Microbiology; Mikrobiologi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. READ MORE

  5. 8. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease

    Author : Anna Tjärnlund-Wolf; Göteborgs universitet; []
    Keywords : tissue-type plasminogen activator; plasminogen activator inhibitor type-1; polymorphism; endothelium; Sp1; gene expression; myocardial infarction; ischemic stroke;

    Abstract : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. READ MORE

  6. 9. Experimental studies of the regulations of synthesis and release of tissue-type plasminogen activator from vascular endothelium

    Author : Lena Selin Sjögren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tissue-type plasminogen activator; endothelium; fluid mechanical forces; shear stress; pressure; immunohistochemistry; gene expression;

    Abstract : The fibrinolytic system has several important functions and one crucial function is the prevention and removal of fibrin deposits in blood vessels. Tissue-type plasminogen activator (t-PA) plays a key role in this process, and in vitro data suggest that an acute release of t-PA is induced as a thromboprotective response whenever clotting mechanisms are initiated. READ MORE

  7. 10. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis

    Author : Wilhelm Ridderstråle; Göteborgs universitet; []
    Keywords : hypertension; left ventricular hypertrophy; intima-media thickness; fibrinolysis; endothelium; tissue plasminogen activator; antihypertensive agents; mechanical stress; plasminogen activator inhibitor-1;

    Abstract : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. READ MORE