Search for dissertations about: "tissue-resident"

Showing result 1 - 5 of 28 swedish dissertations containing the word tissue-resident.

  1. 1. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

    Author : Ajibola Omokanye; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

    Abstract : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. READ MORE

  2. 2. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

    Author : Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

    Abstract : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. READ MORE

  3. 3. Mesenchymal stromal cells in lung tissue

    Author : Sara Rolandsson Enes; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stromal cells; lung transplantation; bronchiolitis obliterans syndrome; obliterative bronchiolitis; extracellular matrix;

    Abstract : Mesenchymal stromal cells (MSC) are multipotent cells with immunomodulatory and regenerative properties. During recent years, the interest in using MSC for clinical approaches for various diseases have increased. READ MORE

  4. 4. Epithelial barrier protection : implications for HIV susceptibility

    Author : Gabriella Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The majority of HIV infections today occur through sexual HIV transmission. The female genital mucosa offers a barrier against incoming pathogens. Although, studies show that the vaginal microbiome, co-current infections and local inflammation, the use of hormonal contraceptives and microbicides, can weaken this protective lining. READ MORE

  5. 5. Matrix metalloproteinases in Helicobacter inducedgastritis

    Author : Philip Bergin; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : ; Helicobacter pylori; Helicobacter felis; Matrix metalloproteinase; macrophage; Gastritis;

    Abstract : Helicobacter pylori infects the stomach and areas of gastric metaplasia in the duodenum. Theinfection leads to peptic ulcers or gastric cancers in 10-20% of infected individuals, while themajority are more or less asymptomatic. However, active chronic gastritis develops in all infectedindividuals, often in association with atrophic gastritis. READ MORE