Search for dissertations about: "tissue-specific knockout"
Showing result 11 - 14 of 14 swedish dissertations containing the words tissue-specific knockout.
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11. Cellular responses to respiratory chain dysfunction
Abstract : Mitochondria are network-like organelles present in most mammalian cells. They contain the respiratory chain (RC) that produces the majority of the energy needed in the cell, in the form of ATP. RC deficiency can arise due to mutations in the mitochondrial DNA (mtDNA) or in nuclear genes encoding mitochondrial proteins. READ MORE
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12. Mitochondrial dysfunction in ageing and degenerative disease
Abstract : The cytoplasm of eukaryotic cells contains a dynamic network of double-membraned organelles, called mitochondria, which perform the process of oxidative phosphorylation (OXPHOS) that provides cellular energy in the form of ATP. The respiratory chain creates an electrochemical gradient across the inner mitochondrial membrane, which drives ATP synthesis by the ATP synthase. READ MORE
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13. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
Abstract : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. READ MORE
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14. Genetic and functional studies on the thyroid hormone axis
Abstract : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. READ MORE
