Search for dissertations about: "tissue-specific knockout"

Showing result 6 - 10 of 14 swedish dissertations containing the words tissue-specific knockout.

  2. 6. Mitochondrial dysfunction in neurodegeneration

    Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE

  4. 7. Genetic modeling of the Hippo pathway in hematopoietic stem cells

    Author : Lina Jansson; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cells; hematopoiesis; Hippo pathway; hematopoietic stem cells;

    Abstract : Hematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. READ MORE

  5. 8. Conditional targeting of the PDGF-B gene

    Author : Maria Enge; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene targeting; Cre loxP; PDGF; pericytes; diabetic retinopathy; brain injury; neurons;

    Abstract : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. READ MORE

  6. 9. Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation

    Author : Olga Beltcheva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nephrin; NPHS 1; CNF; podocytes; promoter;

    Abstract : Kidneys, the main excretory organs in vertebrates, play central role in removing water soluble metabolic waste products from the organism. Many acquired and inherited renal diseases in man lead to kidney dysfunction and nephrotic syndrome - life-threatening condition affecting increasing number of people in the modem society. READ MORE

  7. 10. Regulation of mitochondrial gene expression in metazoa

    Author : Ana Bratic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drosophila melanogaster; ;

    Abstract : Mitochondria are essential organelles of eukaryotic cells and their main function is to provide the cell with the ubiquitously used energy currency ATP. Impaired energy conversion caused by mitochondrial dysfunction is a direct cause of several human diseases. READ MORE