Search for dissertations about: "tissue-specific toxicity"

Showing result 1 - 5 of 12 swedish dissertations containing the words tissue-specific toxicity.

  2. 1. Adrenocorticolysis Induced by 3-MeSO2-DDE : Mechanisms of Action, Kinetics and Species Differences

    Author : Veronica Lindström; Ingvar Brandt; Ulrika Bergström; Eva Brittebo; Hans Tjälve; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Toxicology; 3-methylsulphonyl-DDE; o; p -DDD; CYP11B1; adrenal cortex; tissue-specific toxicity; bioactivation; kinetics; Y-1 cells; Toxikologi; Biology; Biologi;

    Abstract : The DDT metabolite 3-methylsulphonyl-DDE (3-MeSO2-DDE) induces cell death specifically in the adrenal cortex of mice after a cytochrome P45011B1 (CYP11B1)-catalysed bioactivation. This substance is not only an environmental pollutant, but also a suggested lead compound for an improved chemotherapy of adrenocortical carcinoma (ACC). READ MORE

  4. 2. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

    Author : Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE

  5. 3. Estimation of acute toxicity by using the differentiated neuronal progenitor C17.2 cell model

    Author : Jessica Lundqvist; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; C17.2; cell membrane potential; Optimisation culture condition; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The authorities in Europe and United States request information regarding possible toxicity for substances that are produced in one tonne or more per year. Estimation of acute systemic toxicity is conducted in vivo using mice or rats. READ MORE

  6. 4. Zebrafish as a model to study the neuroendocrine system and toxicity of endocrine disruptors

    Author : Gayathri Chandrasekar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Zebrafish is a popular vertebrate model system to study development and perform genetic analysis. It offers numerous advantages such as small size, short generation time, high fecundity, rapid and ex utero development of embryos and optically transparent embryos. READ MORE

  7. 5. Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics

    Author : Tatiana Cantillana; Åke Bergman; Peter Sundin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; o; p -DDD; 3-Methylsulfonyl-DDE; adrenocorticolytic compounds; chiral; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Abstract : DDT was extensively and globally used as a pesticide in agriculture and for malaria vector control from the 1940’s until the 1970’s. Due to its heavy use, DDT became ubiquitously distributed throughout the environment. DDT and several DDT metabolites are persistent organic pollutants. READ MORE