Search for dissertations about: "tlr"
Showing result 1 - 5 of 107 swedish dissertations containing the word tlr.
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1. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy
Abstract : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. READ MORE
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2. Dysregulated mucosal immune responses in microscopic colitis patients
Abstract : Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC) is a common cause of chronic watery diarrhea. The diagnosis relies on typical histopathological changes observed upon microscopic examination. READ MORE
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3. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
Abstract : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. READ MORE
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4. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
Abstract : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. READ MORE
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5. Novel actions of thrombin-derived host defense peptides
Abstract : Thrombin-derived C-terminal peptides (TCPs) constitute a novel class of immunomodulatory host defense peptides, generated during infection and inflammation. Previous investigations have shown that TCPs of 2-3 kDa inhibit pro-inflammatory immune responses in vitro and in vivo, but their mode of action remained unclear. READ MORE