Search for dissertations about: "tomosyn"

Found 3 swedish dissertations containing the word tomosyn.

  2. 1. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Author : Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Abstract : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. READ MORE

  4. 2. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells

    Author : Slavena Andrea Mandic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. READ MORE

  5. 3. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

    Author : Annabelle Forsmark; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

    Abstract : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. READ MORE