Search for dissertations about: "topiramate"

Showing result 1 - 5 of 7 swedish dissertations containing the word topiramate.

  2. 1. Anti-epileptic and neuroprotective mechanisms by Topiramate and Levetiracetam evaluated in primary cultures

    Author : Mikael Ängehagen; Göteborgs universitet; []
    Keywords : calcium imaging; phosphorylation; kainate; glutamate; caffeine; cerebral cortex; hippocampus; field potentials; neurons; astrocytes;

    Abstract : The aim of this thesis was to evaluate plausible intracellular mechanisms of action for antiepileptic drugs, Topiramate (TPM) and Levetiracetam (LEV), and to investigate if TPM possesses neuroprotective properties. The thesis is based on results from calcium imaging, immunohistochemical stainings, viability tests, and Western blot using primary cortical or hippocampal cultures, or hippocampal brain slices. READ MORE

  4. 2. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

    Author : Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

    Abstract : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. READ MORE

  5. 3. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Author : Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. READ MORE

  6. 4. Maternal deprivation and mood stabilizing drugs : effects on rat brain NPY

    Author : Henriette Husum Bak-Jensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Maternal deprivation; stress; mood stabilizing drugs; NPY; mood disorders; depression; anhedonia; Hinders Sensitive Line rats; Amygdala-kindling; microdialysis; RIA; histochemistry.;

    Abstract : Experiences of early adverse life events are more frequent among adult depressed patients than healthy subjects. Studies with non-human primates and rats show that maternal deprivation leads to changes in hypothalamic-pituitary adrenal (HPA)-axis activity/reactivity and increased levels of anxiety and alcohol preference. READ MORE

  7. 5. Newer antiepileptic drugs in women of child-bearing age : pharmacokinetic studies during pregnancy, breastfeeding, and contraception

    Author : Inger Öhman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epilepsy is a common neurological disorder, affecting men and women almost equally. It has been estimated that 0.3 to 0.4% of pregnant women have epilepsy. READ MORE