Search for dissertations about: "toxicity studies"
Showing result 1 - 5 of 485 swedish dissertations containing the words toxicity studies.
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1. Uptake and toxicity of brominated flame retardants and pesticides : Studies on littoral organisms and model communities
Abstract : In this thesis, brackish and freshwater littoral model communities (microcosms) of varying size and complexity were used to study the effects of brominated flame retardants (BFRs) and pesticides. The brackish water microcosms consisted of natural water, sediment and associated organisms, while the larger freshwater microcosms also contained submersed macrophytes (Elodea canadensis). READ MORE
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2. Comparative avian developmental toxicity of PFAAs
Abstract : Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that can commonly be found in environmental matrixes and wildlife from all over the globe. The PFAAs have been used in applications such as water and dirt repelling treatments for textiles, oil-resistant paper coatings and fire-fighting foams. READ MORE
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3. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies
Abstract : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. READ MORE
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4. Anthracyclines : Toxicity and chemotherapy-induced mucositis
Abstract : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. READ MORE
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5. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins : Studies on applications and toxicity
Abstract : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. READ MORE