Search for dissertations about: "toxicity test"
Showing result 21 - 25 of 100 swedish dissertations containing the words toxicity test.
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21. Toxicity pathways in zebrafish cell lines : an ecotoxicological perspective on ”toxicity testing in the 21st century”
Abstract : Standard toxicological in vivo testing has been challenged as the procedures are time-consuming, expensive, and require a large number of animals; given the number of problematic chemicals. Novel toxicological frameworks, such as "toxicity testing in the 21st century", proposed the use of "new approach methods" (in vitro and in silico techniques), that can be applied in high-throughput setups and would allow for the testing of a large number of compounds. READ MORE
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22. Priority setting strategies for regulatory testing of industrial chemicals
Abstract : For the majority of the estimated 70,000 industrial chemical substances available on the European market today there is not enough information to enable a reasonably complete assessment of the risks that they might pose to man and the environment. Any strategy for the generation of additional data for these substances should aim at making testing as efficient as possible taking into account environmental and health protection, time, monetary cost and animal welfare. READ MORE
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23. Development and comparison of in vitro toxicity methods for nanoparticles : Focus on lung cell exposure
Abstract : Concerns for the toxic effects of airborne nanoparticles have been raised along with the increasing production of nanostructured materials. However, the health risks of nanoparticle exposure are currently not fully understood. The most commonly used techniques to study nanoparticle toxicity, both in vivo and in vitro, have several limitations. READ MORE
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24. Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective
Abstract : Do metal particles (including particles of pure metals, alloys, metal oxides and compounds) pose a hazard or risk to human health? In the light of this question, this thesis summarizes results from research conducted on metal particles, and describes the elaboration and implementation of an in vitro test methodology to study metal release from particles through corrosion and dissolution processes in synthetic biological media relevant for human exposure through inhalation/ingestion and dermal contact. Bioaccessible metals are defined as the pool of released metals from particles that potentially could be made available for absorption by humans or other organisms. READ MORE
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25. On enchytraeids and naidids: Life history traits and responses to environmental stress
Abstract : My thesis shows that enchytraeids and naidids are sensitive to various forms of environmental stress, which in combination with the wide distribution of both families make them highly suitable for use in risk assessment and soil monitoring. Enchytraeids were subject to chemical stress under both laboratory and field conditions. READ MORE