Search for dissertations about: "tracer validation"
Showing result 1 - 5 of 17 swedish dissertations containing the words tracer validation.
-
1. Imaging and Quantification of Brain Serotonergic Activity using PET
Abstract : This thesis investigates the potential of using positron emission tomography (PET) to study the biosynthesis and release of serotonin (5HT) at the brain serotonergic neuron. As PET requires probe compounds with specific attributes to enable imaging and quantification of biological processes, emphasis was placed on the evaluation of these attributes. READ MORE
-
2. Development of Methods for Phase System Characterization in Liquid Chromatography
Abstract : The aim of this thesis is first and foremost to improve the fundamental knowledge of nonlinear and preparative separation theory by focusing on some of the remaining “white spots” on the theoretical chromatographic map. Secondly, the acquired knowledge is used to develop, validate and execute new methods for phase characterization in liquid chromatography. READ MORE
-
3. Characterization of [18F]flutemetamol binding properties : A β-amyloid PET imaging ligand
Abstract : The criteria for diagnosing Alzheimer’s disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. READ MORE
-
4. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC
Abstract : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. READ MORE
-
5. Validation of Several Nucleoside Tracers as Proliferation Markers
Abstract : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. READ MORE