Search for dissertations about: "transactivation"

Showing result 11 - 15 of 97 swedish dissertations containing the word transactivation.

  2. 11. cAMP-Regulated Cell Proliferation in Brown Preadipocytes

    Author : Yanling Wang; Jan Nedergaard; Maria Jesus Obregon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fysiologi; Physiology;

    Abstract : As a prototypical second messenger, cAMP is involved in the regulation of multiple cell functions. cAMP has a well established inhibitory effect on cell proliferation in smooth muscle and epithelial cell types. However, there is accumulating evidence also for stimulatory effect on proliferation, mainly in endocrine cell types. READ MORE

  4. 12. Transcriptional regulation of human nuclear encoded mitochondrial genes

    Author : Ahmed Zaid; Richard Scarpulla; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : Biogenesis of mammalian mitochondria requires the participation of both nuclear and mitochondrial genes. This thesis presents studies that characterize the common features of several nuclear encoded mitochondrial promoter genes and proposes the identity of factors regulating the transcription and responsible for coordinated, constitutive expression of diverse mammalian oxidative phosphorylation (OXPHOS) genes. READ MORE

  5. 13. p53 reactivation by the small molecule RITA : molecular mechanisms

    Author : Vera Grinkevich; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. READ MORE

  6. 14. Studies on two transcription regulatory proteins : cellular c-Jun and adenovirus E1A

    Author : Kerstin Sollerbrant; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adenovirus; EIA; EIB; transcription; CtBP; c-Jun; Gal4;

    Abstract : Adenoviruses cause lytic infections in a range of mammalian cells, but can in certain cases also transform the host cell. The first adenovirus gene to be expressed upon infection is E1A. The E1A gene encodes two major proteins of 243 and 289 amino acids, respectively, both of which serve as key regulators during virus infection. READ MORE

  7. 15. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

    Author : Hebin Liu; Sven Påhlman; Umeå universitet; []
    Keywords : RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

    Abstract : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. READ MORE