Search for dissertations about: "transactivation"

Showing result 21 - 25 of 97 swedish dissertations containing the word transactivation.

  2. 21. Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors

    Author : Tobias Cassel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung; C EBP; Cellular Differentiation; Clara Cell Secretory Protein; Development; Gene Expression; Transcriptional Regulation; CYP21B1; Promoter; Synergism; Nkx2.1;

    Abstract : Late lung development is characterised by extensive cellular differentiation, resulting in a variety of specialised epithelial cell types. Although much is known of the extracellular signalling involved in lung morphogenesis, less is currently known of the intracellular developmental mechanisms that govern cellular differentiation. READ MORE

  4. 22. Transcription factors PROX1 and p53 in cancer development

    Author : Tamador Elsir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The majority of malignant brain tumors in adults are astrocytic gliomas. These are classified into four malignancy grades according to the World Health Organization (WHO) criteria, including grade I pilocytic astrocytoma, grade II astrocytoma, grade III anaplastic astrocytoma and grade IV glioblastoma. READ MORE

  5. 23. Mechanisms of activation of the hypoxia-inducible transcription factor 1a

    Author : Sallyann O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors HIF-1 alpha and HIF 1 beta/ARNT. Under hypoxic conditions HIF-1 becomes activated and transcriptionally upregulates a set of target genes involved in angiogenesis, erythropoesis and glycolysis. READ MORE

  6. 24. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms

    Author : Lars-Göran Bladh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoid receptor; glucocorticoids; cross-talk; NF-kappaB; AP-1; cell cycle; cell proliferation;

    Abstract : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. READ MORE

  7. 25. The impact of transcriptional mutagenesis on cellular homeostasis

    Author : Monika Ezerskyte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : DNA is exposed to chemical and physical agents that represent a continuous threat to its integrity by formation of DNA lesions. Despite the existence and efficiency of DNA repair systems in cells, some lesions may not be removed, and interfere not only with the fidelity of DNA replication but also with DNA transcription. READ MORE