Search for dissertations about: "transcription factor binding site"

Showing result 21 - 25 of 116 swedish dissertations containing the words transcription factor binding site.

  2. 21. Orientational dynamics of single molecules applied to protein-DNA target search

    Author : Emil Marklund; Johan Elf; Erwin Peterman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; single molecule imaging; fluorescence correlation spectroscopy; gene regulation; transcription factor; lac operon;

    Abstract : Cells in all life forms regulate their genes with the help of transcription factors (TFs). These proteins turn genes on or off by binding regulatory motifs present in the DNA. Before this binding can occur, a TF needs to search and find the specific binding site in the genome of the cell. READ MORE

  4. 22. Computational and experimental approaches to regulatory genetic variation

    Author : Malin Andersen; Jacob Odeberg; John Peden; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Abstract : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. READ MORE

  5. 23. Studies of the chromatin form of yeast Mediator and the function of its tail module

    Author : Miriam Nilsson; Stefan Björklund; Claes Gustafsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mediator complex; Transcriptional regulation; yeast; tail module; transcription; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Abstract : Mediator is a large, multifunctional complex that is conserved in eukaryotes. It was first discovered in Saccharomyces cerevisiaeas required for transcriptional activators to function in a reconstituted in vitro system. Mediator is also important for stimulation of basal, unregulated transcription, and transcriptional repression. READ MORE

  6. 24. Regulation of HIV-1 provirus transcription

    Author : Mojgan H Naghavi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Key words- HIV-1; LTR; transcription; subtypes; phylogenetic analysis; NFkappaB; USF; MCEF; HMG-1 DSP1; Dorsal.;

    Abstract : Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus activation. READ MORE

  7. 25. The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma

    Author : Bengt Phung; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. READ MORE