Search for dissertations about: "transcription factors"

Showing result 1 - 5 of 820 swedish dissertations containing the words transcription factors.

  1. 1. Functional collaboration between HLH transcription factors in B cell development

    University dissertation from Ramiro Gisler, Stem cell laboratory, BMC, B12, Klinikg.26, 22184 Lund, Sweden

    Author : Ramiro Gisler; Lund University.; Lunds universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Abstract : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. READ MORE

  2. 2. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Alvaro Rada-Iglesias; Uppsala universitet.; [2007]
    Keywords : Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Abstract : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. READ MORE

  3. 3. Maf transcription factors in beta cell function

    University dissertation from Stem Cell Center, Lund University

    Author : Elvira Ganic; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE

  4. 4. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mehdi Motallebipour; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Abstract : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. READ MORE

  5. 5. Inflammatory transcription factors in atherosclerosis

    University dissertation from Hechenbergweg 7, A-6020 Innsbruck

    Author : Wolfgang Dichtl; Lund University.; Lunds universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet;

    Abstract : Transcription factors such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) and peroxisome proliferator-activated receptors (PPARs) may play important roles in atherogenesis, by regulating chronic subclinical vascular inflammation. In the first study, we showed that VLDL activates the proinflammatory transcription factor NF-kB in endothelial cells both in vitro and in vivo. READ MORE