Search for dissertations about: "transcriptional and translational regulation"

Showing result 1 - 5 of 70 swedish dissertations containing the words transcriptional and translational regulation.

  1. 1. Organization and regulation of mitochondrial gene expression

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Roger Salvatori; Martin Ott; Benoit Kornmann; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial gene expression; post-transcriptional regulation; mitochondrial ribosome; protein-protein proximity; BioID; feedback loop; biokemi; Biochemistry;

    Abstract : Mitochondria possess their own genome, remnant of the ancestral eubacterial endosymbiont DNA. This mitochondrial genome encodes mostly few key subunits of the respiratory chain. In order to synthesize these few proteins, mitochondria contain a complete gene expression machinery. READ MORE

  2. 2. Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma

    University dissertation from Division of Translational Cancer Research

    Author : Arash Hamidian; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2α; enChIP; ESRRA; mTORC2; IGF-II; Hypoxia; Cancer; PI3K; Transcription; Neuroblastoma;

    Abstract : Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. READ MORE

  3. 3. Integrating multi-omics for type 2 diabetes Data science and big data towards personalized medicine

    University dissertation from Division of Translational Cancer Research

    Author : Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

    Abstract : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. READ MORE

  4. 4. IGF, PI3K and HIF-2 in Normal and Tumor Development

    University dissertation from Molecular Medicine

    Author : Sofie Mohlin; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Abstract : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. READ MORE

  5. 5. The interactome of the yeast mitochondrial ribosome Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Braulio Vargas Möller-Hergt; Martin Ott; Michal Minczuk; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial post-transcriptional regulation; mitochondrial ribosome; membrane protein insertion; mitochondrial quality control; biokemi; Biochemistry;

    Abstract : The proteins found in mitochondria originate from two different genetic systems. Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into the organelle. However, a small subset of mitochondrial proteins is encoded in an organelle-resident genome. READ MORE