Search for dissertations about: "transdermal drug delivery"

Showing result 1 - 5 of 11 swedish dissertations containing the words transdermal drug delivery.

  2. 1. A Fully Integrated Microneedle-based Transdermal Drug Delivery System

    Author : Niclas Roxhed; Göran Stemme; Mark G. Allen; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microneedle; Transdermal; Intradermal; Drug delivery; DRIE; MEMS; Microsystem; Medical technology; Medicinsk teknik;

    Abstract : Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, conventional transdermal drug delivery is limited to therapeutics where the drug can diffuse across the skin barrier. READ MORE

  4. 2. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Author : Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. READ MORE

  5. 3. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Author : Sebastian Björklund; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Abstract : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. READ MORE

  6. 4. Micromachined Interfaces for Medical and Biochemical Applications

    Author : Patrick Griss; KTH; []
    Keywords : Micromachining; Microsystem Technology; Deep Reactive Ion Etching; Medical Microdevices; Biopotential Electrode; Transdermal Drug Delivery; Electrospray; Mass Spectrometry;

    Abstract : .... READ MORE

  7. 5. ALA and m-ALA in bicontinuous lipid formulations: -Characterization and Transdermal Delivery

    Author : Johanna Bender; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; passive diffusion; SAXS; monoolein; methyl 5-aminolevulinate hydrochloride; NMRD; sponge phase; 5-aminolevulinic acid hydrochloride; iontophoresis;

    Abstract : δ-Aminolevulinic acid (ALA) and its methyl ester (m-ALA) are both used in photodynamic therapy (PDT) of certain non melanoma skin cancers as the basal cell carcinoma (BCC). In PDT the cancer cells are destroyed by a photochemical reaction that occurs when a photosensitive molecule is irradiated with light of a certain wavelength. READ MORE