Search for dissertations about: "transdermal thesis"
Showing result 1 - 5 of 24 swedish dissertations containing the words transdermal thesis.
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1. A Fully Integrated Microneedle-based Transdermal Drug Delivery System
Abstract : Patch-based transdermal drug delivery offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections relating to issues such as patient acceptability and injection safety. However, conventional transdermal drug delivery is limited to therapeutics where the drug can diffuse across the skin barrier. READ MORE
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2. Sampling from a suction induced mini-erosion in human skin. Methodological studies
Abstract : Dermal interstitial fluid (IF) was extracted serially and painlessly by brief suction for as long as 6 days. The erosion was otherwise kept occluded, Sample volumes exceded those required for measuring a wide range of biological substances. Epidermal regeneration was rapid. READ MORE
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3. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis
Abstract : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. READ MORE
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4. Assessment of microvascular function by use of transdermal iontophoresis : methodological aspects
Abstract : Assessment of the microcirculation is of major importance in understanding the physiology of the vasculature and in assessing te vascular effects of pathological conditions such as diabetes, hypertension and sepsis. Transdermal iontophoresis can be used to non‐invasively introduce vasoactive drugs into the skin. READ MORE
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5. Ceramic Materials for Administration of Potent Drugs
Abstract : This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions.Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. READ MORE