Search for dissertations about: "transforming growth factor beta"
Showing result 6 - 10 of 54 swedish dissertations containing the words transforming growth factor beta.
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6. Experimental Models of the Human Peritoneal Environment: Effects of TGF-beta and Hyaluronan
Abstract : BACKGROUND Post surgical adhesion formation is still an unsolved problem and occurs when there is an imbalance between fibrin deposition and fibrin clearing capacity in the abdominal cavity. Transforming growth factor beta (TGF-?) is associated with fibrosis and hyaluronan has in several studies been showed to reduce adhesions. READ MORE
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7. Regulation of Hematopoietic Stem Cells
Abstract : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. READ MORE
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8. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis
Abstract : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. READ MORE
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9. TGF-beta signaling in cancer
Abstract : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. READ MORE
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10. Regulation of hematopoiesis by the Smad signaling pathway
Abstract : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. READ MORE