Search for dissertations about: "transfusion reactions"

Showing result 1 - 5 of 9 swedish dissertations containing the words transfusion reactions.

2. 1. Antibodies during pregnancy : Aspects on complications during pregnancy and complications related to transfusion

   Author : Miodrag Palfi; Olof Sjöberg; Linköpings universitet; []
   Keywords : Pregnancy; Thl; Th2; hernolytic disease of the newborn; anti-D; IgG subclasses; IgG transport; post-transfusion reactions; acute lung injury; MEDICINE; MEDICIN;

   Abstract : The fetus acquires half of its genetic infonnation from the father and represents a foreign graft in pregnancy. The overall mechanisms contributing to immunologic tolerance and successful pregancy still are an enigma. Accumulating results of immunologic research, however, offer an explanation for many events in pregnancy. READ MORE

4. 2. Massive transfusion in relation to obstetric hemorrhage : with special attention to placenta accreta

   Author : Lars Thurn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The overall purpose of this thesis was to assess risk factors, incidences, and complications of massive blood transfusions in relation to obstetric hemorrhage postpartum. Obstetric hemorrhage requiring blood transfusion postpartum has recently shown an increasing trend in many high resource countries. READ MORE

5. 3. Identification and characterisation of SMIM1 variants determining the Vel blood group

   Author : Mikael Kronborg Christophersen; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood groups; Vel blood group system; genetic variation; transcriptional regulation;

   Abstract : The Vel blood group antigen is present on red blood cells from all humans except rare Vel-negative individuals, who can form antibodies to Vel in response to transfusion or pregnancy. It was first described in 1952 as a high incidence antigen, while the molecular background was recently discovered to be a 17-bp deletion in Small Integral Membrane Protein 1, that causes a frame-shift mutation and abolishes SMIM1 expression, thus creating a Vel-negative phenotype. READ MORE

6. 4. Heparin coating and cardiotomy suction in cardiopulmonary bypass

   Author : Staffan Svenmarker; Torkel Åberg; Gunnar Engström; Thomas Karlsson; Jarle Vaage; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; cardiopulmonary bypass; oxygenators; heparin; S100 proteins; blood loss; haemostasis; memory; outcome and process assessment; Kirurgi; Surgery; Kirurgi; kirurgi; Surgery;

   Abstract : The present thesis addresses various means of reducing inflammatory responses associated with cardiopulmonary bypass (CPB) and retransfusion of pericardial suction blood (PSB) during cardiac surgery. Four (I-IV) prospective randomised controlled clinical trials comprising 475 patients were performed in the following areas: effects of heparin coating on measures of clinical outcome and memory function (I, II), inflammatory reactions in PSB and its systemic effects after retransfusion using cardiotomy suction or cell salvage (III) and effects of retransfusion of PSB on memory function and release patterns of protein S100B (IV). READ MORE

7. 5. Studies on the genetic basis of Pk, P and P1 blood group antigen expression

   Author : Åsa Hellberg; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serology; serologi; transplantation; Immunology; SNP; phenotype; erythrocyte; blood group; glycosyltransferase;

   Abstract : The clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. READ MORE