Search for dissertations about: "transgenic mouse"

Showing result 21 - 25 of 285 swedish dissertations containing the words transgenic mouse.

  2. 21. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

    Author : Alina Codita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. READ MORE

  4. 22. Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model

    Author : Sara Brunnberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin Ah Receptor; Arnt; TCDD; gene expression; reproductive tract; bone; heart;

    Abstract : The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to those considered tolerable. The foetus and newborn infant are considered as a particular risk group. READ MORE

  5. 23. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

    Author : Julia Nilsson; Autoimmunitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

    Abstract : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. READ MORE

  6. 24. Expression and function of ribozymes in transgenic mice

    Author : Michael Andäng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hammerhead ribozyme; hairpin ribozyme; transgenic mice; HIV-1; pseudotype virus; cleavage products; cis-cleavage;

    Abstract : Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by cleaving a target RNA after hybridization to complementary sequences. By changing the specific target hybridization sequence of the ribozyme, virtually any RNA can be targeted, making ribozymes a versatile tool for gene down-regulation (knockdown). READ MORE

  7. 25. Modeling PDGF-driven gliomagenesis in the mouse

    Author : Inga Nazarenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of platelet-derived growth factor receptor alpha (PDGFRA) that sometimes occurs together with inactivating mutations or loss of the tumor suppressor p53 (TP53). READ MORE