Search for dissertations about: "translocation"

Showing result 6 - 10 of 496 swedish dissertations containing the word translocation.

  2. 6. Mechanisms and Inhibition of EF-G-dependent Translocation and Recycling of the Bacterial Ribosome

    Author : Anneli Borg; Måns Ehrenberg; Ruben Gonzalez; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein synthesis; Elongation factor G; Translocation; Ribosome recycling; Fusidic acid; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The GTPase elongation factor G (EF-G) is an important player in the complex process of protein synthesis by bacterial ribosomes. Although extensively studied much remains to be learned about this fascinating protein. READ MORE

  4. 7. On Lactobacillus plantarum 299v, bacterial translocation and intestinal permeability

    Author : Peter Mangell; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacterial translocation; permeability; intestinal microflora; Kirurgi; orthopaedics; P-selectin; ortopedi; traumatologi; leukocyte recruitment; Lactobacillus plantarum 299v; traumatology; Surgery; colon resection;

    Abstract : The gastrointestinal tract harbours a huge load of bacteria which exerts important biological functions to maintain health. In certain conditions the relation between commensal bacteria and pathogens may be set off balance, with an increase in number of pathogens and risk of bacterial translocation (BT). READ MORE

  5. 8. Studies of Experimental Bacterial Translocation

    Author : Anders Stenbäck; Cecilia Johnsson; Staffan Meurling; Bengt Jeppsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Intestinal barrier; short bowel syndrome; small bowel transplantation; mesenteric lymph nodes; gadolinium chloride; T cell inactivation; glutamine; phosphatidylcholine; rat; Thiry-Vella loop; Kirurgi; Surgery; Kirurgi;

    Abstract : One of the main obstacles to maintaining patients with short bowel syndrome on parenteral nutrition, or successfully transplanting these patients with a small bowel graft, is the many severe infections that occur. Evidence is accumulating that translocating bacteria from the patient’s bowel causes a significant part of these infections. READ MORE

  6. 9. Ribosomal translocation in real time : Method development to Applications

    Author : Chang-il Kim; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ribosome; EF-G; pyrene mRNA; aminoglycoside; ribosomal protein; GTP hydrolysis; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Translational elongation is the process in which the ribosome adds one amino acid at a time to the nascent peptide chain. As the ribosome elongates the peptide chain by 14 - 20 amino acids per second and performs hundreds of such cycles per protein, ‘elongation’ is one of the most crucial steps in translation. READ MORE

  7. 10. A tale of two antibiotics : Fusidic acid and Viomycin

    Author : Mikael Holm; Suparna Sanyal; Scott Blanchard; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. READ MORE