Search for dissertations about: "transmembrane domain"

Showing result 1 - 5 of 103 swedish dissertations containing the words transmembrane domain.

  1. 1. NA transmembrane domain Amphiphilic drift to accommodate two functions

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Johan Nordholm; Robert Daniels; Ervin Fodor; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; biokemi; Biochemistry;

    Abstract : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. READ MORE

  2. 2. Influenza neuraminidase assembly Evolution of domain cooperativity

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Diogo da Silveira Vieira da Silva; Robert Daniels; Ron Fouchier; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza; neuraminidase; assembly; transmembrane domain; evolution; biokemi; Biochemistry;

    Abstract : Influenza A virus (IAV) is one of the most common viruses circulating in the human population and is responsible for seasonal epidemics that affect millions of individuals worldwide. The need to develop new drugs and vaccines against IAVs led scientists to study the main IAV surface antigens hemagglutinin (HA) and neuraminidase (NA). READ MORE

  3. 3. Membrane Induced Structure in Transmembrane Signaling Proteins and Peptides : Peptide–Lipid Interactions Studied by Spectroscopic Methods

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Sofia E. Unnerståle; Lena Mäler; Jason Schnell; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; paddle domain; voltage gating; voltage sensor domain; micelle; phospholipid bicelle; solution structure; HAMP domain; nuclear magnetic resonance spectroscopy; circular dichroism spectroscopy; nonspecific interaction; Biophysics; biofysik;

    Abstract : Biological membranes, defining the boundary of cells and eukaryotic organelles, are mainly composed of lipids and membrane proteins. Interactions between these lipids and proteins are needed to preserve the tight seal of the membrane, but also to induce structure for proper function in many membrane proteins. READ MORE

  4. 4. Studies on the transmembrane signaling of β1 integrins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika Armulik; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. READ MORE

  5. 5. Mucins, Cystic Fibrosis and PDZ protein interactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emily Malmberg; Göteborgs universitet.; Gothenburg University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

    Abstract : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. READ MORE