Search for dissertations about: "transplanted islets"

Showing result 1 - 5 of 41 swedish dissertations containing the words transplanted islets.

  1. 1. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets

    Author : Gustaf Christoffersson; Mia Phillipson; Kristian Pietras; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; pancreatic islet transplantation; islets of Langerhans; diabetes mellitus; leukocytes; neutrophils; macrophages; pericytes; MMP-9; VEGF-A; Medical Science; Medicinsk vetenskap;

    Abstract : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. READ MORE

  2. 2. Microcirculation in native and transplanted rodent pancreatic islets with special reference to the influence of diabetes mellitus

    Author : Per-Ola Carlsson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; islet microcirculation; microspheres; micropuncture technique; islet blood flow; islet capillary pressure; oxygen tension; transplanted islets; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of the present work was to characterize the islet microcirculation in animal models of type 1 and type 2 diabetes, as well as in islets transplanted to diabetic or normoglycemic recipients. For this purpose, a microsphere technique was evaluated and applied for measurements of islet blood flow in mice. READ MORE

  3. 3. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Author : Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
    Keywords : Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Abstract : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. READ MORE

  4. 4. The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function

    Author : Richard Olsson; Per-Ola Carlsson; Leif Jansson; Arne Andersson; Thomas Linn; Uppsala universitet; []
    Keywords : Cell biology; diabetes mellitus; pancreatic islets; islet transplantation; vascular engraftment; islet microcirculation; oxygenation; blood flow; protein biosynthesis; Cellbiologi;

    Abstract : Type 1 diabetes mellitus affects millions of people worldwide. Islet transplantation is a minimal invasive surgical procedure that restores euglycemia and halts the progression of diabetic complications. However, despite transplantation of islets from multiple donors most patients reverse to hyperglycemia within five years. READ MORE

  5. 5. Microcirculation in Transplanted Islets of Langerhans

    Author : Richard Olsson; Uppsala universitet; []
    Keywords : ;

    Abstract : .... READ MORE