Search for dissertations about: "transplanted islets"

Showing result 16 - 20 of 46 swedish dissertations containing the words transplanted islets.

  2. 16. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

    Author : Andreas Börjesson; Stellan Sandler; Annika Carlsson; Jens Nielsen; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; Medicine; Medicin;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE

  4. 17. The beneficial Effects of Neural Crest Stem Cells on Pancreatic      β–cells

    Author : Anongnad Ngamjariyawat; Elena Kozlova; Leif Jansson; Jens Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural Crest Stem Cells; Pancreatic Islets; β-cell proliferation; β-cell survival; Cadherin; Medical Science; Medicinsk vetenskap;

    Abstract : Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. READ MORE

  5. 18. Modulation of the Immune Response in Concordant Xenotransplantation

    Author : Adam Bersztel; Gunnar Tufveson; Michael Olausson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Antibodies; blood transfusions; heart; pancreatic islets; tolerance; xenotransplantation; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Xenotransplantation, i.e. transplantation between different species, could be a possible solution to the present shortage of organ donors. The immunological response to a xenograft is strong and difficult to suppress. READ MORE

  6. 19. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

    Author : Daniel Espes; Per-Ola Carlsson; Joey Lau; Mia Phillipson; Eelco de Koning; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. READ MORE

  7. 20. Expression and Regulation of Neuropeptide Y (NPY) in the Islets of Langerhans

    Author : Ulrika Myrsén Axcrona; Neuroendokrin cellbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; regulatory peptides; diabetes; glucocorticoids; beta cell; islet hormones; neuropeptide Y; insulin; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : This thesis deals with the expression, localization and regulation of neuropeptide Y (NPY) in the pancreatic islets of Langerhans under normal and experimental conditions. NPY is widely distributed in the mammalian nervous system and belongs to a family of closely related petides also comprising peptide YY (PYY) and pancreatic polypeptide (PP). READ MORE