Search for dissertations about: "treatment cascade"

Showing result 1 - 5 of 111 swedish dissertations containing the words treatment cascade.

  2. 1. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs

    Author : Julius Semenas; Jenny L. Persson; Anna Berghard; Maria Fällman; Thomas Grundström; Lukas Kenner; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; bone metastasis; castration-resistant; treatment; precision therapy; PIP5K1A; steroid hormone receptors; cancer stem cells; Oncology; onkologi;

    Abstract : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men.  The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. READ MORE

  4. 2. The Burden of Epilepsy : using population-based data to define the burden and model a cost-effective intervention for the treatment of epilepsy in rural South Africa

    Author : Ryan G Wagner; Lars Lindholm; Lars Forsgren; Charles Newton; Andrea Winkler; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Africa; epilepsy; incidence; mortality; cause of death; disability-adjusted life years; out-of-pocket; costs; health care utilization; treatment cascade; adherence; intervention; economic evaluation; community health worker;

    Abstract : Rationale Epilepsy is a common, chronic, neurological condition that disproportionately affects individuals living in low- and middle- income countries, including much of sub-Saharan Africa. Epilepsy is treatable, with the majority of individuals who take anti-epileptic drugs experiencing a reduction, or elimination, of seizures. READ MORE

  5. 3. Effects of Flow Structure on Particle Separation in Dissolved Air Flotation

    Author : Måns Lundh; Institutioner vid LTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; plasma; Environmental technology; pollution control; Miljöteknik; kontroll av utsläpp; Gases; fluid dynamics; plasmas; Gaser; fluiddynamik; Teknik; Technological sciences; modelling; retention time distribution; acoustic doppler velocimeter; flow structure; separation; water treatment; wastewater treatment;

    Abstract : Dissolved Air Flotation (DAF) is a separation process in water and wastewater treatment. The removal function is based on reducing the density of the particle by producing aggregates of the particles and added micro-bubbles of air, thus lifting the aggregates to the water surface, where they can be removed as sludge. READ MORE

  6. 4. Alzheimer disease : subcellular Aβ mechanisms and treatment strategies

    Author : Yang Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular level and explore effective AD treatment strategies. READ MORE

  7. 5. Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment

    Author : Karina Roxana Gheorghe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss of function. This condition affects 0. READ MORE