Search for dissertations about: "treatment of leukemia"

Showing result 1 - 5 of 267 swedish dissertations containing the words treatment of leukemia.

  2. 1. Hairy cell leukemia : with special reference to in vitro effects of alpha-interferon treatment

    Author : Inaam Bashir Hassan; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Chronic lymphocytic leukemia : Studies from genetics to epidemiology with focus on the impact of different treatments

    Author : Mattias Mattsson; Richard Rosenquist; Clemens Wendtner; Uppsala universitet; []
    Keywords : Chronic lymphocytic leukemia; genetics; epidemiology; Klinisk genetik; Clinical Genetics; Epidemiologi; Epidemiology;

    Abstract : The progress in our understanding of the biology and pathophysiology of chronic lymphocytic leukemia (CLL), as well as the development of new treatments, necessitates additional research on; (i) the impact of different therapies within subgroups of CLL patients, (ii) solid epidemiological data on the prevalence of CLL and on comorbidities within the CLL population, and (iii) new means of prognostication, as the value of traditional prognostic markers is uncertain when applied to new treatments.In paper I we studied the efficacy of chemo(immuno)therapy in stereotyped subsets #1 and #2. READ MORE

  5. 3. Mechanisms of leukemia-induced immunosuppression

    Author : Johan Aurelius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Abstract : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. READ MORE

  6. 4. Registry-Based Studies in Adult Acute Lymphoblastic Leukemia in Sweden : Survival and Quality of Life

    Author : Emma Bergfelt Lennmyr; Helene Hallböök; Martin Höglund; Jan Maxwell Nørgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Lymphoblastic Leukemia; Philadelphia Chromosome; Overall Survival; Population-based; Quality Registry; Relapse; Patient-Reported Outcome; Health-Related Quality of Life; Depression;

    Abstract : Acute lymphoblastic leukemia (ALL), a common child malignancy, also constitutes a minor fraction of adult cancer with approximately 50 new cases per year in Sweden. While the five-year overall survival (OS) in pediatric ALL is more than 90%, the prognosis in adults is dismal. READ MORE

  7. 5. Chronic lymphocytic leukemia : Studies on cardiovascular disease, biomarkers and subclones

    Author : Karin Larsson; Martin Höglund; Geir Tjønnfjord; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : Chronic lymphocytic leukemia; cardiovascular disease; population-based; biomarkers; subclones; Medicinsk vetenskap; Medical Science;

    Abstract : The treatment of Chronic lymphocytic leukemia (CLL) is rapidly changing, with targeted therapies, e.g. Bruton’s tyrosine kinase inhibitors (BTKi), entering the frontline and relapse setting. However, BTKis have significant adverse effects, most notably cardiovascular disease (CVD). READ MORE