Search for dissertations about: "trichostatin"

Showing result 1 - 5 of 12 swedish dissertations containing the word trichostatin.

  2. 1. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    Author : Steven Gray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE

  4. 2. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate

    Author : Karolina Wallenborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. READ MORE

  5. 3. Gene silencing and expression during mammalian development : The special case of the imprinted H19 gene

    Author : Kristian Svensson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi; zoologisk utvecklingsbiologi; Animal Development;

    Abstract : Embryonic development consists of a vast number of fine-tuned, complex processesthat organise the body plan and individual organs. To enable developmental decisions,genes pivotal for normal development must be stably activated and silenced, asappropriate. READ MORE

  6. 4. Patterning during embryo development in Pinus : with special emphasis on somatic embryogenesis in Scots pine (Pinus sylvestris L.)

    Author : Malin Abrahamsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Somatic embryogenesis is an attractive method to propagate conifers vegetatively. However, many species belonging to Pinus are recalcitrant to somatic embryo development. The overall aim of this thesis has been to gain a better understanding of the developmental pathway leading to cotyledonary somatic embryos of Scots pine (Pinus sylvestris). READ MORE

  7. 5. Histone deacetylases and their co-regulators in schizosaccharomyces pombe

    Author : Rebecka A. Silverstein; Karl Ekwall; Anthony Wright; Fred Van Leeuwen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. READ MORE